Product Introduction
CAS Number: 1192491-61-4
Standard: In-house standard
Avibactam sodium is a non-β-lactam β-lactamase inhibitor used in combination with ceftazidime to treat complicated intra-abdominal infections and complicated urinary tract infections caused by multi-drug resistant gram-negative bacterial pathogens.
Applications
Avibactam sodium, a non-β-lactam β-lactamase inhibitor, has diverse applications in combating multi-drug resistant gram-negative bacterial pathogens.
Avibactam sodium has the following key applications:
1. Restoring the antimicrobial properties of partner cephalosporins against multi-drug resistant gram-negative bacterial pathogens in vitro[5]
2. Treating complicated intra-abdominal infections in combination with metronidazole
3. Treating complicated urinary tract infections, including pyelonephritis, caused by antibiotic resistant pathogens
4. Inhibiting various classes of β-lactamases, including class A (KPCs, CTX-M, TEM, SHV), class C (AmpC), and some class D serine β-lactamases, to combat antibiotic resistance
5. Potential for oral bioavailability through prodrug analogues with sulfate esters and carboxylate esters, which can be cleaved under mild conditions to release unesterified avibactam
Avibactam sodium is a significant development in treating infections caused by multi-drug resistant gram-negative bacteria, as it can restore the efficacy of partner antibiotics and inhibit various β-lactamases.
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