Human Prostaglandins

Bioactive Lipid Compounds & Essential Pharmaceutical Ingredients

Your Professional Human Prostaglandins Supplier

Xiamen Origin Biotech Co., Ltd. , a certified 'State Hi-tech Enterprise,' specializes in the integration of R&D, manufacturing, and sales of human and veterinary APIs and intermediates. The company's product portfolio encompasses hormones, proteins and peptides, prostaglandins, small molecule compounds, and other APIs. These products are widely applied in the fields of reproduction, endocrinology, and gynecology, catering to both human and veterinary requirements.

Customized Services

Xiamen Origin provides tailored solutions for product development and R&D services for new products, aligning with specific customer demands.

Pharmaceutical Production Expertise

Our team possesses extensive experience in pharmaceutical manufacturing and is equipped with the technical expertise required to meet diverse client needs effectively.

Rigorous Quality Assurance

We implement stringent quality control protocols at every stage of production, from raw material inspection to environmental monitoring, ensuring compliance with the highest industry standards.

Advanced Infrastructure

Our manufacturing facility spans 2,523 m², including a Class D cleanroom of 365 m². Designed and constructed in strict adherence to GMP regulations.

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Prostaglandins are bioactive lipid compounds that play important roles in various physiological processes in the human body. They are involved in regulating inflammation, blood flow, hormone production, and other biological functions. Some prostaglandins are also used as active pharmaceutical ingredients (APIs) in medical treatments.

For this category, Origin Biotech has the products like Latanoprost, (-)-Corey Lactone Diol, Travoprost, etc.

Latanoprost is a prostaglandin analog primarily used in ophthalmology to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It belongs to the class of medications known as prostaglandin F2alpha analogs. Latanoprost works by increasing the outflow of aqueous humor from the eye, which helps to reduce intraocular pressure. This can help prevent damage to the optic nerve and preserve vision. Latanoprost is available in various forms such as eye drops, ophthalmic solutions, and ophthalmic implants. It is typically prescribed as a once-daily medication for long-term use.

(-)-Corey Lactone Diol , also known as Latanoprost acid, is the active metabolite of Latanoprost. After topical administration of Latanoprost, it is hydrolyzed to (-)-Corey Lactone Diol in the eye. This metabolite retains the pharmacological activity of Latanoprost and contributes to its therapeutic effects in reducing intraocular pressure.

Travoprost is another prostaglandin analog used in the treatment of open-angle glaucoma and ocular hypertension. It is a synthetic derivative of prostaglandin F2alpha and shares a similar mechanism of action with Latanoprost. Like Latanoprost, Travoprost increases the outflow of aqueous humor from the eye, leading to a reduction in intraocular pressure. It is available as an ophthalmic solution for topical application and is also prescribed once daily.

Both Latanoprost and Travoprost have proven to be effective in managing glaucoma and ocular hypertension by reducing intraocular pressure. However, the choice of medication may vary based on individual patient characteristics, including their specific medical condition, response to treatment, and potential side effects. It is important for patients to follow the instructions provided by their healthcare professionals and use the medications as directed.

In conclusion, prostaglandins such as Latanoprost and Travoprost are valuable APIs used in the treatment of glaucoma and ocular hypertension. These medications effectively reduce intraocular pressure and help preserve vision.

Welcome to inquire about human API products, please believe that Origin Biotech will provide you with high-quality products, preferential prices, and considerate services.

Parameter Specifications

Specification	Latanoprost	Travoprost
Molecular Formula	C22H36O5	C26H35F3O6
Molar Mass	380.52	500.55
Density	1.118	1.245±0.06 g/cm3 (Predicted)
Melting Point	97-100°C	/
Boiling Point	550.6±50.0 °C (Predicted)	584.8±50.0 °C (Predicted)
Flash Point	300.9°C	17°C
Solubility	DMF: Soluble	DMF: Soluble
Appearance	Crystalline	Ethanol solution
PKa	4.78±0.10 (Predicted)	13.43±0.20 (Predicted)
Storage Condition	-20°C	Sealed in dry, Freezer, Under -20°C

Types of Human Prostaglandins

The human prostaglandins produced by our company mainly include the following types:

01. (+)-Corey Lactone Diol

Corey lactone diol is an essential intermediate compound used in the synthesis of various pharmaceutical drugs. The compound is used to produce antiviral, anti-inflammatory, and anti-cancer drugs. It has a unique chemical structure that makes it easy to modify and fine-tune its properties to meet specific therapeutic requirements.

02. Corey Lactone Benzoate

Corey Lactone Benzoate, also known as CLB, is a versatile and valuable compound widely used in multiple industries due to its unique chemical properties. This colourless or pale yellow crystalline solid is soluble in many organic solvents and has a distinctive odor, making it useful in various applications.

03. Latanoprost

Latanoprost is an effective medication used to treat glaucoma and reduce intraocular pressure, helping to prevent further vision loss and improve overall eye health.

The Role of Human Prostaglandins

Biological System	Physiological Effect
Digestive system	Reduction of acid secretion; Increase of mucous secretion; Longitudinal smooth muscle contraction; Circulatory smooth muscle contraction
Respiratory system	Bronchodilator; Bronchoconstriction
Cardiovascular system	Arterial vasodilation; Inhibition of platelet adhesion and leukocyte aggregation
Renal system	Medullar blood flow, Pressure diuresis; Renin release; Natriuresis, Diuresis
Immune system	Inhibition of proliferation and activation of T and B lymphocytes
Central nervous system	Inflammation; Induction of sleep
Female reproductive system	Ovulation, Implantation, Endometrial contraction, and Synergism with oxytocin
Male reproductive system	Fertility

Analysis Methods

Mass Spectrometry (MS)

Precisely determines mass-to-charge ratio. Offers high sensitivity for low concentrations and excellent identification of unique mass spectra.

LC-MS Analysis

Combines liquid chromatography separation with MS power. Provides high-resolution mass spectra and quantitative accuracy using internal standards.

Tandem MS/MS

Uses multiple mass analyzers for structural elucidation. Fragment prostaglandin ions to determine double bond positions and side chain nature.

Packaging and Shipping

Packaging	We have different sizes of glasses and Foil bags, you can request small separate packages or complete packages.
Shipping	Once your order has been placed, we will process it as soon as possible. We usually deliver the package by airfreight and insure your purchase against accidental damage and being shipped on time.

Our Certifications

FAQ

Q: How do prostaglandins influence the respiratory system?

A: In the respiratory system, prostaglandins can cause bronchoconstriction or bronchodilation depending on the type. For example, PGF2α can cause bronchoconstriction, while PGE2 and PGI2 have bronchodilatory effects. They also play a role in the inflammatory response in the lungs, such as in conditions like asthma.

Q: Do prostaglandins have any effects on the gastrointestinal tract?

A: Yes, prostaglandins have several effects on the gastrointestinal tract. They help to protect the gastric mucosa by stimulating the secretion of mucus and bicarbonate, which helps to prevent damage from stomach acid. They also regulate intestinal motility and can affect the absorption and secretion of substances in the intestines.

Q: What is the role of prostaglandins in the reproductive system?

A: In the female reproductive system, prostaglandins are involved in ovulation, menstruation, and labor. They can cause uterine contractions, which are important for the process of childbirth. In the male reproductive system, prostaglandins are present in semen and may play a role in sperm motility and function.

Q: What is the basic structure of prostaglandins?

A: Prostaglandins are based on a 20-carbon fatty acid backbone called prostanoic acid. They have a five-membered ring and various side chains that determine their specific functions and properties.

Q: What regulates the synthesis of prostaglandins?

A: The synthesis of prostaglandins is regulated by a variety of factors. Hormones, cytokines, and other signaling molecules can stimulate or inhibit the enzymes involved in prostaglandin synthesis. For example, tissue injury or inflammation can trigger the release of cytokines that activate the enzyme cyclooxygenase (COX), which is a key enzyme in the synthesis of prostaglandins.

Q: Can the body control the levels of prostaglandins?

A: Yes, the body has several mechanisms to control prostaglandin levels. The synthesis of prostaglandins can be regulated at the transcriptional and translational levels of the enzymes involved. Additionally, prostaglandins are rapidly metabolized and inactivated by specific enzymes, such as prostaglandin dehydrogenase, which helps to maintain the appropriate levels of prostaglandins in the body.

We're well-known as one of the leading human prostaglandins manufacturers and suppliers in China. If you're going to buy high quality human prostaglandins with competitive price, welcome to get more information from our factory. Also, customized service is available.

Carboprost Trometamina, 155206-00-1, 130209-82-4