(–)-Corey Lactone Diol
Chiral Intermediate for Asymmetric Synthesis & Pharmaceutical Development
(–)-Corey Lactone Diol is a highly valuable chiral cyclic compound featuring a distinctive structure that contains both a lactone ring and hydroxyl functional groups. This unique structural design enables a wide range of stereoselective and asymmetric synthetic transformations, making it an essential intermediate in advanced organic and pharmaceutical synthesis. Named after the renowned chemist EJ Corey, this compound represents a cornerstone of modern chiral chemistry and asymmetric synthesis.
CAS Number: 32233-40-2 | Standard: In-house
Product Description
Chiral cyclic lactone diol
Lactone ring + hydroxyl groups
Optically active (–)-enantiomer
Pharmaceutical, fine chemicals, and advanced research
The precise stereochemistry of (–)-Corey Lactone Diol allows chemists to construct complex molecules with excellent control over three-dimensional structure.
Applications
1. Asymmetric Synthesis
(–)-Corey Lactone Diol is widely used as a chiral building block in asymmetric synthesis. Its inherent stereochemistry enables the production of enantiomerically pure compounds, which is essential in:
▸Pharmaceutical development
▸ Agrochemical synthesis
▸ Biologically active molecule production
Its use significantly improves selectivity, yield, and optical purity.
2. Total Synthesis of Natural Products
This compound plays a vital role in the total synthesis of complex natural products, including:
▸ Alkaloids
▸ Terpenoids
▸ Polyketides
Its ability to introduce controlled chirality and enable key carbon–carbon bond formation makes it indispensable in mimicking complex biosynthetic pathways.
3. Pharmaceutical Intermediates & API Development
In pharmaceutical manufacturing, (–)-Corey Lactone Diol is a critical intermediate for chiral pharmaceutical intermediates and active pharmaceutical ingredients (APIs). Its stereochemical precision ensures:
▸ Enhanced drug efficacy
▸ Reduced side effects
▸ Improved pharmacokinetic profiles
4. Catalytic Asymmetric Reactions
(–)-Corey Lactone Diol is also widely employed in catalytic asymmetric transformations, such as:
▸ Asymmetric hydrogenation
▸ Asymmetric allylation
▸ Enantioselective carbon–carbon bond formation
It functions as both a substrate and chiral auxiliary, enabling high enantiomeric excess and sustainable synthetic processes.
Summary
(–)-Corey Lactone Diol is a highly versatile, optically active pharmaceutical intermediate that plays a central role in:
Enantiomerically pure building blocks for complex molecules.
Key role in total synthesis of alkaloids, terpenoids, and polyketides.
Precision stereochemistry for enhanced API efficacy and safety.
Substrate and chiral auxiliary for high enantiomeric excess.
Its ability to deliver precise stereochemical control makes it a cornerstone material in modern organic chemistry, pharmaceutical research, and industrial drug manufacturing.
Source (–)-Corey Lactone Diol
We supply high-purity (–)-Corey Lactone Diol with full manufacturing documentation and batch traceability - from R&D evaluation samples through to bulk supply.
Contact our team to discuss how (–)-Corey Lactone Diol can support your next synthesis project.
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