Product Introduction
CAS Number: 39746-00-4
Standard: In-house
Corey Lactone Diol is an important intermediate in organic synthesis, particularly known for its use in the synthesis of prostaglandins and other complex natural products.
Applications
Corey Lactone Diol is a versatile chemical compound with significant applications in pharmaceutical research and synthesis. This compound, with the molecular formula C8H12O4, serves as a key intermediate in the preparation of various pharmaceutical agents, natural products, and pesticides.
One of the primary applications of Corey Lactone Diol is its use in the synthesis of Iloprost, a medication with inhibitory activity towards β-lactamase. Iloprost is a synthetic analogue of prostacyclin (PGI2) and is used to treat pulmonary arterial hypertension and Raynaud's phenomenon.
Corey Lactone Diol is available in high purity (at least 98.0%) as a white to almost white powder or crystal, with a melting point ranging from 114.0 to 118.0 °C. This high purity makes it suitable for various research applications, including the synthesis of prostaglandin hormones, which play essential roles in physiological processes and can have medicinal applications.
Furthermore, the optically active form of Corey Lactone Diol can be easily obtained through an optical resolution method involving selective acylation of the primary hydroxyl group by an acylating agent and an enzyme or microorganism, followed by separation and purification of the residual Diol and formed ester. This method highlights the compound's versatility and potential for use in stereoselective synthesis.
In summary, Corey Lactone Diol is a crucial intermediate in the pharmaceutical industry, enabling the synthesis of various therapeutic agents, including Iloprost, and serving as a valuable tool in prostaglandin research and development.
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