Corey Lactone Diol
Essential Chiral Intermediate for Prostaglandin Synthesis
Corey Lactone Diol is a highly important chiral intermediate in organic and pharmaceutical synthesis. It is best known for its critical role in the synthesis of prostaglandins and other structurally complex natural products. Due to its stable structure and high reactivity, it is widely used in advanced drug research and development.
CAS Number: 39746-00-4
Standard: In-house
Product Overview
- ▸ Molecular Formula: C₈H₁₂O₄
- ▸ Appearance: White to off-white powder or crystalline solid
- ▸ Purity: ≥ 98.0%
- ▸ Melting Point: 114.0 – 118.0 °C
With excellent chemical stability and high purity, Corey Lactone Diol is well-suited for laboratory research, pharmaceutical synthesis, and industrial applications.
Applications
Corey Lactone Diol is a versatile compound with wide-ranging applications in the pharmaceutical and chemical industries:
1. Prostaglandin Synthesis
It serves as a key building block in the synthesis of various prostaglandin hormones, which play essential roles in inflammation, blood flow regulation, and reproductive processes.
2. Iloprost Production
One of its most important applications is in the synthesis of Iloprost, a synthetic analogue of prostacyclin (PGI₂), used for the treatment of:
- ▸ Pulmonary arterial hypertension (PAH)
- ▸ Raynaud's phenomenon
3. Research & Development
- ▸ Pharmaceutical R&D and natural product synthesis
- ▸ Advanced stereoselective reactions
- ▸ Fine chemical and pesticide synthesis
- ▸ Optical Activity & Stereoselective Synthesis
The optically active form of Corey Lactone Diol can be efficiently obtained through optical resolution techniques, including:
- ▸ Selective enzymatic acylation of the primary hydroxyl group
- ▸ Separation of the formed ester and unreacted diol
- ▸ Final purification to achieve high enantiomeric purity
This makes it especially valuable for chiral drug synthesis and stereochemically precise research.
Summary
Corey Lactone Diol is a high-purity, reliable, and widely used pharmaceutical intermediate. Its importance in prostaglandin chemistry, Iloprost production, and stereoselective synthesis makes it an essential compound for modern pharmaceutical research and industrial drug manufacturing.
Chemical Synthesis Excellence
Supporting global drug development with high-purity chiral building blocks.
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