Leuprorelin Acetate is a synthetic gonadotropin-releasing hormone (GnRH) analogue that can inhibit the secretion of gonadal hormones and is widely used in human and animal medicine.
Application in Human Medicine
1. Prostate Cancer: Leuprorelin Acetate is mainly used to treat hormone-dependent prostate cancer. It continuously stimulates the pituitary GnRH receptors, resulting in a decrease in the secretion of gonadotropins (LH and FSH), thereby inhibiting the production of testosterone and slowing down tumor progression.
2. Endometriosis: This drug can be used to treat endometriosis, reduce estrogen levels, thereby relieving pain and inhibiting the development of lesions.
3. Breast Cancer: For some hormone receptor-positive breast cancer patients, Leuprorelin Acetate can reduce estrogen levels and reduce the stimulation of tumor growth.
4. Central precocious puberty: used for early-onset puberty in children, delaying the closure of growth plates, and allowing children to grow longer.
5. Assisted reproductive technology (ART): used to control ovulation time and improve the success rate of in vitro fertilization (IVF).
Application in veterinary medicine
1. Pet sterilization: Leuprorelin Acetate can be used for temporary chemical sterilization, inhibiting the secretion of reproductive hormones in dogs, cats and other animals, and reducing estrus behavior.
2. Livestock reproduction control: In animal husbandry, the drug is used to regulate the estrus cycle of animals such as pigs and cattle and improve the success rate of artificial insemination.
3. Treatment of certain hormone-related diseases: For example, it can be used to treat prostate diseases and breast tumors in dogs, and control the estrus cycle of horses.
4. Experimental animal research: Leuprorelin Acetate is often used in medical research to establish hormone-dependent disease models, such as hormone-dependent tumors or menopausal models, to study the efficacy of new drugs.
In conclusion, Leuprorelin Acetate plays an important role in both human and animal medicine, mainly in the treatment of hormone-related diseases and regulation of the reproductive system.