Chorionic Gonadotrophin for Injection
Mechanism, Indications & Veterinary Applications
Chorionic Gonadotrophin for Injection (HCG) is a gonadotrophic hormone derived from natural sources, widely used in veterinary medicine to regulate and support reproductive function across a variety of animal species. Its dual FSH-like and LH-like activity makes it a uniquely versatile tool in clinical and aquaculture settings.
This knowledge article covers the pharmacological profile, mechanisms of action, clinical indications, dosing guidelines, precautions, and product specifications for Chorionic Gonadotrophin for Injection, manufactured by Xiamen Origin Biotech Co., Ltd.
What is Chorionic Gonadotrophin (HCG)?
Chorionic gonadotrophin (HCG) is a glycoprotein hormone that mimics the actions of two key pituitary hormones - follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The injectable formulation appears as white lyophilized masses or powder, reconstituted for use prior to administration.
Its sulfated carbohydrate-rich structure enables it to:
▸ Stimulate reproductive hormone production in both sexes
▸ Induce ovulation and support corpus luteum development in females
▸ Promote testicular development and androgen secretion in males
▸ Trigger spawning in aquaculture broodstock species
Pharmacological Action
HCG exerts its biological effects through two distinct pathways depending on the sex of the animal. Its actions are receptor-mediated, binding to LH and FSH receptors in target reproductive tissues.
In Females
HCG acts primarily on ovarian tissue, where it triggers a cascade of reproductive events:
▸ Promotes corpus luteum formation following ovulation
▸ Stimulates progesterone secretion to support gestation
▸ Induces ovulation in mature follicles
▸ Has no effect on immature follicles - action is follicle-stage dependent
In Males
In male animals, HCG acts on testicular Leydig cells, producing androgenic and developmental effects:
▸ Stimulates differentiation of Leydig cells and androgen secretion
▸ Promotes development and maturation of genital organs and secondary sexual characteristics
▸ Can induce testicular descent in cryptorchid animals without anatomical abnormalities
Principal Advantages
HCG offers a range of clinically significant advantages that make it a preferred reproductive hormone in veterinary practice.
Combines FSH-like and LH-like effects in a single injectable preparation.
Effective across horses, cattle, sheep, swine, dogs, and aquaculture species.
Addresses sexual dysfunction, habitual abortion, and ovarian cysts.
Used to induce spawning in silver carp and bighead carp broodstock.
Safe for use in food-producing animals without mandatory withdrawal.
Indications and Usage
Chorionic Gonadotrophin for Injection is indicated for the following clinical and production contexts:
1. Sexual Dysfunction
HCG is used to restore and stimulate reproductive performance in animals with reduced or absent sexual function, addressing underlying hormonal deficits in both males and females.
2. Habitual Abortion
By stimulating progesterone secretion via corpus luteum support, HCG helps maintain pregnancy in animals prone to recurrent spontaneous abortion due to luteal insufficiency.
3. Ovarian Cysts
HCG is effective in resolving cystic ovarian conditions by triggering ovulation of mature follicles, restoring normal ovarian cyclicity in affected animals.
4. Induction of Spawning in Aquaculture
In fish reproduction management, HCG is injected intraperitoneally to trigger spawning in broodstock:
▸ Silver carp (Hypophthalmichthys molitrix)
▸ Bighead carp (Hypophthalmichthys nobilis)
Dosage and Administration
Intramuscular Administration - Livestock & Companion Animals
▸ Horses & Cattle: 1,000–5,000 IU per dose
▸ Sheep: 100–500 IU per dose
▸ Swine: 500–1,000 IU per dose
▸ Dogs: 25–300 IU per dose
Frequency: Administer 2–3 times per week.
Intraperitoneal Injection - Broodfish
Injection site: At the base of the pectoral or pelvic fin.
▸ Female silver & bighead carp: 1,000–2,000 IU/kg body weight per dose
▸ Male broodfish: Half the female dose
Adverse Reactions
No adverse reactions have been reported when the product is used as directed. As with all injectable biologics, aseptic technique is recommended during preparation and administration.
Precautions
▸ Prolonged use: Not recommended - may induce antibody formation against HCG and suppress endogenous pituitary gonadotrophin function over time.
▸ Reconstituted solution stability: Highly unstable and heat-sensitive after reconstitution. Must be used promptly after preparation and must not be stored for later use.
Withdrawal Period & Storage
Not required. No mandatory withholding time before slaughter or use of animal products.
Store in tight, well-sealed containers. Protect from light. Keep at a temperature not exceeding 20°C.
Product Specifications
500 IU per vial
1,000 IU per vial
2,000 IU per
vial 5,000 IU per vial
10,000 IU per vial
50,000 IU per vial
10 vials per box
About Xiamen Origin Biotech Co., Ltd.
Origin Biotech is dedicated to providing premium veterinary biological products with scientific rigour and regulatory compliance. Our injectable HCG is manufactured to the highest quality standards for reliable reproductive performance in clinical and production animal settings.
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No. 9-5 Xianghai 2nd Road, Xiang'an Torch High-Tech Industrial Development Zone, Xiamen, Fujian, China
361101
+86-592-7073986