Trilostane API
Gold Standard Treatment for Canine Hyperadrenocorticism
CAS Number: 13647-35-3
Quality Standard: In-house Standard
Therapeutic Class: Adrenal Steroid Synthesis Inhibitor
Trilostane is a well-established active pharmaceutical ingredient (API) widely used in veterinary medicine, particularly for the treatment of Cushing's disease (hyperadrenocorticism) in dogs. It functions by inhibiting cortisol production in the adrenal glands, helping to restore hormonal balance and improve the clinical health of affected animals.
Mechanism of Action
Trilostane is a synthetic steroid analogue that selectively blocks enzymes involved in cortisol synthesis. By inhibiting $3\beta$-hydroxysteroid dehydrogenase, it prevents the overproduction of cortisol-an essential hormone that, in excess, leads to severe metabolic and immune complications.
Clinical Benefits in Dogs
Reduces excessive thirst (polydipsia) and urination (polyuria).
Controls abnormal weight gain and improves skin/coat health.
Enhances energy levels and restores overall animal well-being.
Safety & Efficacy
Clinical studies indicate that up to 95% of dogs treated with Trilostane experience significant symptomatic improvement.
▸ Generally well-tolerated for long-term veterinary use.
▸ Predictable safety profile under proper veterinary monitoring.
▸ Managed side effects (vomiting/lethargy) are typically transient.
The Origin Advantage
✔ High Purity: Consistent batch quality for pharmaceutical production.
✔ Direct Manufacturer: Competitive pricing with no intermediary markups.
✔ Quality Systems: Manufactured under rigorous, monitored control systems.
✔ Reliable Supply: Scalable volumes to meet global veterinary demand.
Frequently Asked Questions
A: We are a direct manufacturer with our own specialized production facility, allowing for strict oversight and transparent pricing.
A: Every batch undergoes multi-stage QC, from raw material validation to final assay testing, ensuring 100% compliance with our standards.
Partner with Origin Biotech
We offer professional technical support and regulatory documentation for Trilostane API supply. Contact our commercial team for batch-specific documentation and volume-based pricing.
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