Trilostane API
Veterinary & Human Corticosteroid Regulator
Trilostane is a potent inhibitor of 3β-hydroxysteroid dehydrogenase, widely used in veterinary and human medicine. It is primarily indicated for the treatment of Cushing's syndrome, primary hyperaldosteronism, and several adrenal-related hormonal disorders. Due to its effectiveness in regulating excess corticosteroid production, Trilostane is frequently recommended for dogs, cats, and horses with hyperadrenocorticism (HAC). It may also benefit certain breeds suffering from alopecia-related conditions such as Alopecia X in Pomeranians and adult-onset alopecia in Alaskan Malamutes.
Product Details
|
Parameter
|
Specification
|
|---|---|
| Molecular Formula | C₂₀H₂₇NO₃ |
| Molar Mass | 329.43 g/mol |
| Density | 1.1213 (estimated) |
| Melting Point | 264 °C |
| Boiling Point | 467.02 °C (estimated) |
| Specific Rotation (α) | D25 +137.4° (c = 1, pyridine) |
| Flash Point | 254.8 °C |
| Solubility | DMSO ≥ 17 mg/mL |
| Vapor Pressure | 5.39E-12 mmHg at 25°C |
| pKa | 8.57 ± 0.70 (predicted) |
| Refractive Index | 1.5614 (estimated) |
| Appearance | Powder |
| Color | White to almost white |
| Storage | Store in a tightly sealed, airtight container |
Applications
✔ Treatment for Cushing's Syndrome
Trilostane is commonly used to treat pituitary- and adrenal-dependent hyperadrenocorticism (HAC) in dogs, cats, and horses. It suppresses corticosteroid synthesis, helping reduce symptoms like excessive thirst, increased urination, hair loss, and fatigue.
✔ Treatment of Primary Hyperaldosteronism
This condition is characterized by high aldosterone production. Trilostane promotes electrolyte homeostasis and alleviates related clinical symptoms.
✔ Supportive Treatment for Alopecia Disorders
Trilostane therapy benefits specific breeds:
- Pomeranians with Alopecia X
- Alaskan Malamutes with Adult-onset Alopecia
The medicine helps restore hormonal balance connected with hair follicle health.
✔ Adjunctive Therapy for Post-menopausal Breast Cancer
Trilostane can be used to treat recurrent breast cancer in postmenopausal women by lowering adrenal hormone levels, which contribute to tumor formation.
How Trilostane Works
Corticosteroids are essential for:
- The metabolism of lipids, proteins, and carbohydrates
- Stress response
- Regulation of salt and water balance
- Excess corticosteroid output causes serious health problems
Trilostane inhibits the manufacture of corticosteroids, hence stabilizing hormone levels and successfully controlling symptoms.
Packaging & Delivery Options
- Express Services: FedEx, DHL
- Air transportation offers fast and secure choices for large orders
Sales & Services
Xiamen Origin Biotech is committed to expanding its worldwide reach and forming long-term collaborations. Our strengths include:
- Premium product quality
- Strong technical support
- Professional sales and after-sales services
Our products are exported worldwide, including Europe, North America, South America, the Middle East, and Asia, and we consistently receive positive feedback from customers.
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