D-Cloprostenol Sodium
CAS 62561-03-9 | Veterinary Reproductive Management API
D-Cloprostenol Sodium (CAS No. 62561-03-9) is a synthetic prostaglandin analogue widely used as an active pharmaceutical ingredient (API) in veterinary medicine. As a potent and selective analogue of Prostaglandin F2α (PGF2α), it plays a critical role in regulating reproductive functions in livestock, making it indispensable for modern animal husbandry and veterinary reproductive management programs.
Chemical Profiles and Characteristics
|
Feature |
Description |
|---|---|
| Chemical Formula | C₂₂H₂₉ClO₆ |
| Molecular Weight | Approx. 416.92 g/mol |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in water, ethanol, and methanol |
| pH | Neutral (around pH 7) |
| Storage | Store at room temperature in a cool, dry environment |
| Stability | Stable under recommended storage conditions |
| Standard | In-house standard |
The compound's chemical stability, solubility, and purity make it suitable for formulation in various veterinary pharmaceutical preparations.
Mechanism of Action
As a PGF2α analogue, D-Cloprostenol Sodium works primarily by inducing luteolysis-the breakdown of the corpus luteum-which leads to the regulation of the estrous cycle and induction of parturition. Its targeted action provides predictable and reliable results, which is essential in reproductive management across multiple animal species.
Veterinary Applications
D-Cloprostenol Sodium is widely used in cattle, horses, and pigs due to its strong luteolytic and uterotonic effects. Its main therapeutic and management uses include:
1. Induction of Parturition (Cows, Pigs)
One of the most valuable applications of D-Cloprostenol Sodium is its ability to induce labor in cattle. This controlled induction ensures:
▸ Timely calving
▸ Reduced risk of dystocia (difficult births)
▸ Improved management of herd reproduction schedules
Its use contributes significantly to safer deliveries for both cows and calves, enhancing reproductive efficiency on farms.
2. Treatment of Reproductive Disorders in Cattle
D-Cloprostenol Sodium is effective in managing several key reproductive issues, especially:
Cystic Ovarian Disease
Cystic ovaries prevent normal ovulation, decreasing fertility and prolonging the calving interval. D-Cloprostenol Sodium helps by:
▸ Reversing ovarian abnormalities
▸ Restoring normal ovulatory cycles
▸ Improving conception rates
This is particularly important for dairy farmers, whose productivity depends heavily on consistent reproductive performance.
3. Regulation of the Estrous Cycle in Horses
In mares, the compound is commonly used to treat:
Silent Heat
Silent heat occurs when a mare experiences estrus without displaying outward behavioral signs. D-Cloprostenol Sodium helps by:
▸ Synchronizing the estrous cycle
▸ Inducing ovulation at predictable intervals
▸ Increasing breeding success rates
This makes it a valuable tool for equine breeders seeking optimal control over reproductive timing.
4. Uterine Health Support
The prostaglandin effect of D-Cloprostenol Sodium also assists in:
▸ Managing postpartum hemorrhage
▸ Supporting uterine involution
▸ Treating certain uterine infections (eg, pyometra, endometritis)
These contribute benefits to quicker recovery post-calving and a shorter return to fertility.
Advantages in Veterinary Practice
D-Cloprostenol Sodium offers several practical and economic advantages:
▸ Precision in reproductive scheduling - allowing farmers to plan breeding and calving more efficiently
▸ Enhanced fertility outcomes - particularly in animals with ovulatory dysfunction
▸ Improved herd management - synchronizing multiple animals for breeding programs
▸ High efficacy at low dosages - increasing safety and reducing costs
Its predictable physiological responses make it a reliable choice across veterinary reproductive protocols.
Conclusion
D-Cloprostenol Sodium (CAS 62561-03-9) is a vital API in the veterinary pharmaceutical landscape, offering powerful benefits in reproductive management for cattle, horses, and other livestock species. Its efficiency in inducing parturition, normalizing ovulation, and treating reproductive disorders underscores its crucial role in supporting animal health, optimizing breeding programs, and enhancing farm productivity.
With its robust performance, stability, and broad veterinary utility, D-Cloprostenol Sodium remains an indispensable tool for veterinarians and livestock producers worldwide.
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