Peforelin (also known as tirelin or thyrotropin-releasing hormone, TRH) is a synthetic tripeptide hormone widely used in animal medicine and research. Its main function is to stimulate the release of thyroid-stimulating hormone (TSH) and prolactin (PRL) from the anterior pituitary gland, thereby affecting thyroid function and the lactation process in animals. The following are the main applications of Peforelin in animals:
1. Diagnosis of thyroid function:
Peforelin is commonly used to diagnose abnormal thyroid function in animals. By injecting Peforelin, the response of the pituitary-thyroid axis can be assessed to help identify primary hypothyroidism from secondary hypothyroidism. This is particularly common in pets such as dogs and cats, especially when thyroid disease is suspected.
2. Promotes lactation:
In animal husbandry, Peforelin is used to promote lactation in animals such as cows and goats. By stimulating the release of prolactin, Peforelin increases milk secretion and thus milk production. This is of great significance in improving the economic benefits of animal husbandry.
3. Research on the neuroendocrine system:
Peforelin is widely used in experimental animal research, especially in the field of neuroendocrinology. By injecting Peforelin, researchers observe its effect on the release of pituitary hormones and then explore the regulation mechanism of thyroid hormones, prolactin and other hormones.
4. Treatment of neurological disorders:
Peforelin has also been used to treat certain neurological disorders. Studies have shown that TRH has a neuroprotective effect and can improve motor function and nerve conduction in animals. In some experimental models, Peforelin has been used to treat spinal cord injury, cerebral ischaemia and other neurological disorders.
5. Reproductive management:
In reproductive management, Peforelin has also been used to regulate reproductive functions in animals. By affecting the secretion of prolactin, Peforelin can indirectly influence the oestrous cycle and reproductive behaviour of animals, thereby improving reproductive efficiency.
Overall, Peforelin has a wide range of applications in animal medicine and research, covering diagnostic, therapeutic, and reproductive management. It influences the metabolism, lactation and neurological functions of animals by regulating the release of pituitary hormones, providing important support for animal health and livestock development.
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