Urokinase
Thrombolytic Enzyme for Clot Dissolution
CAS Number: 9039-53-6
Standard: In-house Grade
Category: Thrombolytic / Fibrinolytic Enzyme
Function: Potent serine protease used for clot dissolution
Product Overview
Urokinase is a powerful fibrinolytic enzyme widely used in modern clinical medicine for its exceptional ability to break down and dissolve blood clots. As a therapeutic thrombolytic agent, it plays a critical role in restoring blood flow in life-threatening and obstructive vascular conditions such as deep vein thrombosis (DVT), pulmonary embolism (PE), and catheter occlusions.
Our Urokinase API is manufactured under strict in-house quality standards and is designed for pharmaceutical formulation, research, and clinical applications requiring high potency and purity.
Key Features
▸ High-activity serine protease specifically targeting fibrin-rich clots
▸ Consistent potency suitable for injectable or catheter-directed formulations
▸ In-house quality specifications with batch-wise COA and analytical documentation
▸ Ideal for clinical, hospital, and research-grade use
Applications of Urokinase
Urokinase is widely utilized across multiple therapeutic areas due to its ability to dissolve thrombi and rapidly restore circulation. Major medical applications include:
1. Acute Ischemic Stroke
Urokinase helps dissolve blood clots blocking cerebral arteries, restore brain perfusion and reduce neurological damage when administered early.
2. Pulmonary Embolism (PE)
Used in moderate to severe PE cases to lyse obstructive clots in the lung arteries, improving oxygenation and preventing right-heart overload.
3. Deep Vein Thrombosis (DVT)
Administered via catheter-directed thrombolysis (CDT) to break down clots in deep veins, restore venous flow and reducing the risk of post-thrombotic syndrome.
4. Peripheral Arterial Thrombosis
Helps dissolve occlusions in limb arteries, improving circulation and reducing the risk of tissue loss or limb ischemia.
5. Catheter Occlusion Clearance
Urokinase effectively restores patency of central venous catheters by dissolving clots inside the lumen-widely used in oncology, dialysis, and long-term IV therapy.
6. Acute Myocardial Infarction (AMI)
Though less frequent today compared to tPA, urokinase has been used to dissolve clots in coronary arteries during heart attacks.
7. Renal Vein Thrombosis
Assists in relieving venous obstruction, preserving renal function, and improving clinical outcomes.
8. Other Investigational Uses
Urokinase continues to be studied for:
▸ Acute limb ischemia
▸ Mesenteric artery thrombosis
▸ Various occlusive vascular diseases
Why Urokinase Remains an Important Thrombolytic Agent
▸ Fast and targeted clot dissolution
▸ Well-established clinical history
▸ Useful in patients where alternative therapies are not suitable
▸ Compatible with catheter-directed precision dosing
Summary
Urokinase API is an essential therapeutic enzyme in the management of thrombotic disorders, offering reliable, effective clot dissolution across a wide range of clinical conditions. Its versatility in emergency, vascular, and interventional therapies makes it a vital tool for healthcare professionals worldwide.
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