Urokinase

Properties, Applications & Advantages

Urokinase (CAS 9039-53-6) is a clinically significant thrombolytic enzyme used to dissolve blood clots and restore normal blood flow. Derived from human urine or cell culture systems, it activates plasminogen into plasmin, enabling rapid fibrin degradation in pathological clots.

This article provides a comprehensive overview of its properties, mechanism of action, medical applications, and manufacturing strengths-serving as a valuable reference for researchers, clinicians, and pharmaceutical developers.

Product Overview

▸ Product Name: Urokinase
▸ CAS Number: 9039-53-6
▸ Appearance: White to yellowish powder
▸ Molecular Formula: C21H25BrN2O3
▸ Solubility: Soluble in water
▸ Storage: 2–8°C, protected from light

Urokinase is a naturally occurring serine protease enzyme that breaks down fibrin , the structural framework of blood clots, making it a powerful therapeutic agent in thrombotic disorders.

Mechanism of Action

Urokinase converts plasminogen into plasmin , the enzyme responsible for fibrin degradation. Activated plasmin dissolves fibrin networks and clears vascular blockages.

▸ Binds fibrin within the clot
▸ Activates plasminogen → plasmin
▸ Breaks fibrin into soluble fragments
▸ Restores blood flow

Clinical & Research Applications

▸ Deep vein thrombosis (DVT)
▸ Pulmonary embolism (PE)
▸Acute myocardial infarction
▸ Ischemic stroke and cerebrovascular disorders
▸ Catheter occlusions and arterial embolism
▸ Blood coagulation and fibrosis research

Advantages of UK Urokinase Production

GMP-Compliant Manufacturing

Advanced cleanroom facilities ensuring pharmaceutical-grade purity.

Strict Quality Control

Multi-stage testing from raw materials to final product.

Professional Technical Support

Customized solutions, documentation, and regulatory guidance.

Conclusion

UK Urokinase (CAS 9039-53-6) remains one of the most effective thrombolytic agents in modern medicine. Supported by robust GMP manufacturing and strict quality assurance, it is a trusted solution for clinical treatment, pharmaceutical development, and biomedical research.