Changes in sexual hormones during menopause

After a woman enters menopause, her menstrual cycle gradually decreases and eventually stops. The cessation of menstruation is the result of ovarian dysfunction.
Menstruation is a response to periodic ovarian activity. During pre menopause, about one or two years before menopause, the periodic activity of the ovaries has begun to change. The earliest change is a decrease in the sensitivity of the ovaries to pituitary gonadotropins. The follicles only develop to a certain extent, i.e., they are self locked, without ovulation, or the formation of a corpus luteum. At this time, although there is still menstruation, this is anovulatory menstruation. Later, the ovarian function further decreases, not only does it fail to form a corpus luteum, but the follicles also stop developing, and the periodic activity of the ovaries stops, resulting in a cessation of menstruation.
During menopause, a series of changes have taken place in the endocrine environment of the human body. During pre menopause, the follicles still secrete estrogen, but the level of progesterone (progesterone) secreted by the corpus luteum is significantly reduced, resulting in an imbalance in the ratio of estrogen to progesterone, with estrogen taking a comparative advantage. By menopause, estrogen levels gradually decrease. From an endocrine perspective, the transition from imbalance to rebalancing is the main characteristic of menopause.