Pimobendan for Dogs
Cardiac Support in Veterinary Medicine
Pimobendan is a widely used veterinary drug for treating congestive heart failure (CHF) in dogs. Particularly effective for dilated cardiomyopathy (DCM) and degenerative mitral valve disease (DMVD), it is a potent inodilator that enhances both cardiac contraction and blood vessel dilation, improving cardiac output and quality of life.
Product Overview
- Chemical Name: Pimobendan
- CAS Number: 74150-27-9
- Standard: EP 10.0, In-house
- Appearance: White or slightly yellowish powder
- Storage: −20°C, protected from light, airtight
Property Details
- Molecular Formula: C₁₉H₁₈N₄O₂
- Molar Mass: 334.37 g/mol
- Solubility: Soluble in DMSO (5 mg/mL)
- pKa: 10.55 ± 0.10
- Form: Powder
Mechanism of Action
Pimobendan improves cardiac function in dogs via two complementary mechanisms: positive inotropy and vasodilation. Together, these effects enhance circulation, cardiac output, and overall quality of life.
- Positive Inotropy: Increases calcium sensitivity, strengthens heart contractions for efficient blood pumping.
- Vasodilation: Relaxes blood vessels, reducing resistance and cardiac workload.
- Reverse Cardiac Remodeling: Slows structural heart changes, supporting better long-term cardiac performance.
Applications
- Congestive Heart Failure (CHF): Improves survival and comfort in affected dogs.
- Dilated Cardiomyopathy (DCM): Supports weakened heart muscles and enhances cardiac output.
- Degenerative Mitral Valve Disease (DMVD): Reduces regurgitation from valve leakage and improves circulation.
Administration & Safety
Pimobendan is administered orally and generally well tolerated. Side effects may include vomiting, diarrhea, or reduced appetite. Veterinary supervision and regular monitoring are recommended.
Conclusion
Pimobendan (CAS 74150-27-9) remains a cornerstone therapy for canine heart disease. By improving heart contraction and promoting vasodilation, it enhances cardiac performance, comfort, and longevity in dogs with CHF and related cardiac conditions.