Serum Gonadotrophin is a biological product derived from animal serum, most commonly from the blood of pregnant mares. It contains two key active hormones: Follicle Stimulating Hormone (FSH) and Luteinising Hormone (LH). Because of its origin, it is also widely known as Pregnant Mare Serum Gonadotropin (PMSG). This hormone plays a crucial role in regulating ovarian and testicular function, making it an important tool in both animal husbandry and assisted reproductive reproduction reproduction reproduction medicine.
Main Uses of Serum Gonadotrophin
1. Animal reproduction
In animal husbandry, Serum Gonadotrophin API is frequently used to enhance reproductive performance. By inducing estrus and ovulation in female animals, PMSG injections improve breeding efficiency, increase conception rates, and help achieve larger litter sizes.
2. Assisted Reproductive Medicine
In human fertility treatments, Serum Gonadotrophin serves as a hormonal therapeutic agent. It is used in assisted reproductive technologies such as in vitro fertilisation (IVF), where it promotes multiple follicular development in the ovaries. This controlled stimulation increases the chances of successful egg retrieval and fertilisation.
Preparation and properties
1. Source
Extracted primarily from the serum of pregnant mares, followed by a multi-step purification process to ensure high purity and biological activity.
Active Ingredients:
- FSH (Follicle Stimulating Hormone) – stimulates the growth of ovarian follicles and sperm production
- LH (Luteinising Hormone) – triggers ovulation and supports hormone production in reproductive organs
2. Formulations
Commonly available as injectable solutions or lyophilised powders. These formulations must be stored under controlled low-temperature conditions to preserve biological activity.
Quality requirements
The production of Serum Gonadotrophin APIs requires strict quality control . Standards are usually defined by the International Pharmacopoeia , ensuring:
- High purity and potency of FSH and LH activity
- Low impurity levels
- No viral or bacterial contamination
These measures guarantee the safety and effectiveness of the product in both medical and veterinary applications.
Conclusion
Serum Gonadotrophin (PMSG) is a valuable biological product with widespread applications in animal husbandry and assisted reproductive medicine. Its ability to regulate reproductive functions makes it essential in promoting fertility, while its preparation demands strict adherence to international quality standards to ensure safety and efficacy.