Dimevamide is an anticholinergic drug used primarily to relieve spasms of the smooth muscles of the gastrointestinal tract and to reduce gastric acid secretion. In animals, the mechanism of action of Dimevamide is similar to its action in humans, mainly by blocking the binding of acetylcholine to receptors and inhibiting the activity of the parasympathetic nervous system, thus exerting antispasmodic and inhibitory secretion effects.
1. Antispasmodic effects
Dimevamide is effective in relieving smooth muscle spasms in the gastrointestinal, biliary and urinary tracts. In animal experiments, Dimevamide reduces excessive contraction of smooth muscle by inhibiting the action of acetylcholine, thus relieving pain and discomfort caused by spasm. For example, in models of gastrointestinal disorders, Dimevamide significantly reduces abnormal peristalsis in the intestines and improves the animals' digestive function.
2. Inhibition of gastric acid secretion
Dimevamide reduces the secretion of gastric acid by blocking cholinergic receptors on the cells of the stomach wall. In animal experiments, Dimevamide was able to significantly reduce the production of gastric acid, thereby alleviating the symptoms of gastric ulcer and gastritis caused by excessive gastric acid. This is important for the study of animal models of gastric acid-related diseases.
3. Sedative effect
Dimevamide has a certain central sedative effect, which can reduce the anxiety and restlessness of animals. In the experiment, Dimevamide can reduce the stress response of animals by inhibiting the cholinergic activity of the central nervous system, making them more quiet and relaxed.
4. SIDE EFFECTS
Despite its significant antispasmodic and inhibitory secretory effects in animals, Dimevamide may cause some side effects such as dry mouth, dilated pupils, and increased heart rate. These side effects are associated with the blockade of cholinergic receptors and usually fade away after the drug is metabolised.
5. Application Prospects
The application of Dimevamide in animal experiments provides an important tool for the study of gastrointestinal disorders, biliary disorders and gastric acid-related diseases. Further study of its mechanism of action and side effects can provide a theoretical basis for the development of safer and more effective drugs.
In conclusion, the effects of Dimevamide in animals are mainly reflected in antispasmodic, inhibition of gastric acid secretion and sedation, which provide an important experimental basis for the study and treatment of related diseases.
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