Neostigmine Methyl Sulfate
Cholinesterase Inhibitor for Neuromuscular and Pharmacological Research
Neostigmine Methyl Sulfate (CAS Number: 51-60-5) is a well-known cholinesterase inhibitor widely used in clinical medicine and biomedical research. It primarily acts at the neuromuscular junction, where it enhances cholinergic transmission by inhibiting acetylcholinesterase, leading to increased levels of acetylcholine.
Manufactured according to in-house quality standards, Neostigmine Methyl Sulfate is commonly used in neuromuscular research, anesthesia recovery studies, toxicology, cardiac research, and gastrointestinal motility investigations, particularly in animal models.
Product Overview
▸ Chemical Name: Neostigmine Methyl Sulfate
▸ CAS Number: 51-60-5
▸ Standard: In-house
▸ Chemical Classification: Cholinesterase inhibitor
▸ Primary Action: Enhances neuromuscular transmission
Physical & Chemical Properties
C₁₃H₂₂N₂O₆S
334.39 g/mol
White crystalline powder
~150°C (decomposes)
Soluble in water
Controlled RT (20–25°C)
Mechanism of Action
Neostigmine Methyl Sulfate works by reversibly inhibiting acetylcholinesterase, the enzyme responsible for breaking down acetylcholine. This inhibition increases acetylcholine concentration at the neuromuscular junction, improving nerve impulse transmission and muscle contraction.
Research & Animal Study Applications
1. Neuromuscular Disease Research
Commonly used in animal models of myasthenia gravis to:
▸ Study neuromuscular transmission
▸ Evaluate muscle weakness and fatigue
▸ Assess new therapeutic compounds
2. Post-Anesthesia Recovery Studies
▸ Reverse neuromuscular blockade
▸ Restore spontaneous breathing and reflexes
3. Cardiac and Gastrointestinal Studies
Essential for examining autonomic regulation and smooth muscle motility:
▸ Vagal regulation of heart rate
▸ Stimulation of intestinal smooth muscle contraction
▸ Restoration of normal GI motility
Neostigmine Methyl Sulfate remains a versatile and essential compound for laboratory and preclinical studies due to its reliable performance and well-understood mechanism.
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