Cloprostenol Injection
Prostaglandin Precision for Reproductive Control
Cloprostenol is a synthetic prostaglandin that enables precise control over reproductive cycles in cattle and swine. Its dual action makes it essential for modern breeding programs and parturition management.
How It Works
Dual Mechanism
▸ Luteolytic Activity: Causes corpus luteum regression, removing progesterone's block on cycling
▸ Uterine Stimulation: Directly triggers smooth muscle contraction for parturition
Primary Applications
Induces corpus luteum regression in cattle, allowing entire groups to return to estrus simultaneously for batch artificial insemination. Critical component of Ovsynch protocols.
Controls farrowing timing in sows at 112-113 days gestation, enabling births during optimal staffing hours and reducing piglet mortality.
Dosing Guidelines
▸ Cattle: 2-3 mL per dose (intramuscular)
▸ Sows (112-113 days gestation): 0.5–1 mL per dose (intramuscular)
Ovsynch Protocol Role
Cloprostenol is the essential prostaglandin in the Ovsynch protocol for timed AI:
▸ Day 0: GnRH injection
▸ Day 7: Cloprostenol injection (regresses corpus luteum)
▸ 48 Hours Later: Second GnRH injection
▸ 18-20 Hours After: Timed AI
Important Precautions
Timing Critical in Swine
Use only at 112-113 days gestation in sows. Late gestation use may increase dystocia risk and reduce efficacy. Always verify gestational age and ensure supervision during expected farrowing.
Storage
Store in tight, light-protected containers at ≤20°C. Zero withdrawal period for meat and milk.
Operational Benefits
Eliminates heat detection and optimizes staffing schedules
Batch processing for better herd and litter management
Higher conception rates and reduced piglet mortality
Conclusion
Cloprostenol delivers precise prostaglandin control essential for modern reproductive management. Whether synchronizing dairy herds or controlling farrowing, this proven tool maximizes efficiency while maintaining excellent safety profiles. When used according to protocols, it consistently delivers the reproductive control that drives profitable operations.
Precision Prostaglandin Solutions
Origin Biotech provides pharmaceutical-grade Cloprostenol formulated for consistent luteolytic activity and reliable synchronization outcomes in cattle and swine reproductive programs.